For Intraoperative Management of Clear Corneal Incisions
Terry Kim, MD
The Importance of the ReSure Sealant
Michael Raizman, MD
The ReSure Sealant for a Patient with Marfans Syndrome
Arsham Sheybani, MD
Procedural Reference Guide1
This is not a substitute for the ReSure Sealant Instructions for Use. For complete instructions including indication for use, warnings, and precautions, please refer to the ReSure Sealant Instructions for Use.
Prior to application, ensure incision site is not actively leaking. Remove any standing moisture from the surrounding conjunctival surface and ensure that the site is dry.
Select one channeled well for mixing and add two drops of Diluent to the blue deposit. Do not add any drops to the white deposit in the same channeled well.
NOTE: 1 package contains material for 2 applications.*
*40% of clinical trial subjects required >2 applications (ie, >1 package). It may be necessary to open additional packages to achieve full coverage.
Mixing and Applying1
Mixing and applying ReSure Sealant must be complete in less than 30 seconds. In vitro gel times suggest mixing and applying ReSure Sealant in less than 20 seconds.2,3
Use the applicator to thoroughly and rapidly mix the solutions using a back and forth motion (about 5 seconds).
Holding the applicator handle with the side edge of the foam tip facing down, gently dip the foam tip into the solution, picking up the material.
Apply over the entire length, width and edges of the incision, ensuring full coverage of the margins.
Delay introduction of any ophthalmic drops to the ocular surface for approximately 30 seconds after application of ReSure Sealant to ensure polymerization of the material and complete adherence and coverage of the target area.
The blue color serves as a visualization aid to ensure proper placement of ReSure Sealant, and diffuses from the hydrogel within hours of application.
- Stop manipulation of the applicator if liquid material stranding is observed. If application to the incision site was not completed prior to stranding, prepare the second channeled well and reapply.
- ReSure Sealant may be removed carefully with forceps if necessary.
- Each applicator is intended for single-use only. If a second application is required, use a new applicator.
- When full coverage of the incision cannot be achieved (including incisions with brisk/copious leaks, or incisions for which a temporary dry surface cannot be achieved), and for incisions at higher risk of postoperative wound leak, ReSure Sealant should not be used and suture placement should instead be considered.
References: 1. ReSure Sealant [instructions for use]. Bedford, MA: Ocular Therapeutix, Inc; LCN 80-1004-011 Rev C. 2. Mah FS. J Ocul Pharmacol Ther. 2016;32(6):396-399. 3. Food and Drug Administration. FDA Summary of Safety and Effectiveness Data. https://www.accessdata.fda.gov/cdrh_docs/pdf13/P130004b.pdf. Accessed March 24, 2021.